Cytomegalovirus and Kaposi's sarcoma in young homosexual men

Lancet. 1982 Jul 17;2(8290):125-7. doi: 10.1016/s0140-6736(82)91092-3.

Abstract

10 homosexual men with Kaposi's sarcoma (KS) were studied for evidence of cytomegalovirus (CMV) infection. IgG and IgM antibodies to CMV were detected in 9 out of 9 and in 7 out of 9 of these patients, respectively. CMV was recovered from body secretions or peripheral blood of 7 patients. Viral cultures of KS tumour biopsy specimens were negative in 8 out of 8 patients, but CMV RNA was detected by in-situ hybridisation in 2 out of 3 and CMV antigen(s) by immunofluorescence in 6 out of 9. Normal tissue specimens from 3 KS patients were negative for CMV antigen. These observations suggest an association of CMV with KS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Antibodies, Viral / analysis
  • Cytomegalovirus / immunology*
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / complications*
  • Homosexuality*
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Male
  • Middle Aged
  • RNA, Viral / analysis
  • Sarcoma, Kaposi / etiology*
  • Sarcoma, Kaposi / immunology
  • Tumor Virus Infections / immunology

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • RNA, Viral