Abstract
Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.
MeSH terms
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Adolescent
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Adult
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Aged
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Animals
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Antipsychotic Agents / adverse effects
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Atrophy
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Brain / metabolism
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Brain / pathology*
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Dopamine / metabolism
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Dopamine beta-Hydroxylase / cerebrospinal fluid*
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Homovanillic Acid / cerebrospinal fluid*
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Humans
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Middle Aged
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Phenylacetates / cerebrospinal fluid*
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Rats
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Schizophrenia / cerebrospinal fluid*
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Tomography, X-Ray Computed
Substances
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Antipsychotic Agents
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Phenylacetates
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Dopamine beta-Hydroxylase
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Dopamine
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Homovanillic Acid