High-dose intravenous melphalan for plasma-cell leukaemia and myeloma

Lancet. 1983 Oct 8;2(8354):822-4. doi: 10.1016/s0140-6736(83)90739-0.

Abstract

1 previously untreated patient with plasma-cell leukaemia and 8 patients with myeloma (4 previously untreated) were treated with high-dose melphalan 100-140 mg/m2 iv. All responded to treatment. 3 of the 5 previously untreated patients achieved biochemical and bone-marrow complete remissions.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Bence Jones Protein / urine
  • Bone Marrow Transplantation
  • Female
  • Humans
  • Injections, Intravenous
  • Leukemia, Plasma Cell / drug therapy*
  • Leukemia, Plasma Cell / therapy
  • Male
  • Melphalan / administration & dosage*
  • Melphalan / adverse effects
  • Middle Aged
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / therapy
  • Neutropenia / chemically induced
  • Pain Management
  • Transplantation, Autologous

Substances

  • Bence Jones Protein
  • Melphalan