Abstract
Using [3H]ethylketocyclazocine after suppression of mu, delta and sigma binding by 100 nM DAGO + 100 nM DADLE + 10 microM phencyclidine we showed the existence of a subclass of kappa sites insensitive to dynorphins 1-9 and 1-17, and alpha and beta neoendorphins, but sensitive to the non-peptidic opiates. The dynorphin-sensitive site probably corresponds to the "standard" kappa site while the importance of the dynorphin-resistant site remains to be established.
MeSH terms
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Analgesics, Opioid / metabolism
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Animals
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Binding, Competitive
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Brain / metabolism*
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Cell Membrane / metabolism
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Cyclazocine / analogs & derivatives
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Cyclazocine / metabolism
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Ethylketocyclazocine
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Guinea Pigs
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Male
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Phencyclidine / pharmacology
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Receptors, Opioid / drug effects
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Receptors, Opioid / metabolism*
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Receptors, Opioid, kappa
Substances
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Analgesics, Opioid
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Receptors, Opioid
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Receptors, Opioid, kappa
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Ethylketocyclazocine
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Phencyclidine
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Cyclazocine