[Isolation and identification of antigen-specific T-cell-receptors (author's transl)]

J Clin Chem Clin Biochem. 1980 Jan;18(1):1-5.
[Article in German]

Abstract

Experimental allergic encephalomyelitis was induced by injection of myelin basic protein into guinea pigs strain 13. Specific antigen binding T-cell receptors were isolated by means of a nylon net coupled with antigen. A phage immunoassay was set up as an analytical tool for detection of the receptors. They were found not to be identical with common immunoglobulins and have a molecular weight of 71,000.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Encephalomyelitis, Autoimmune, Experimental / chemically induced
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Epitopes
  • Guinea Pigs
  • Immunoassay / methods
  • Immunoglobulins / analysis
  • Molecular Weight
  • Myelin Basic Protein
  • Receptors, Antigen, T-Cell / analysis*
  • Receptors, Antigen, T-Cell / isolation & purification
  • T-Phages

Substances

  • Epitopes
  • Immunoglobulins
  • Myelin Basic Protein
  • Receptors, Antigen, T-Cell