Cell cultures from bone affected by Paget's disease

Arthritis Rheum. 1980 Oct;23(10):1115-20. doi: 10.1002/art.1780231007.

Abstract

Cells obtained from Paget's bone specimens were maintained in culture for up to 8 1/2 months. The cells had several characteristics of bone cells including the presence of alkaline phosphatase, acid phosphatase, or succinic dehydrogenase as demonstrated histochemically. Electron microscopy revealed nuclear inclusions similar to those found in the osterclasts of Paget's disease in 4 or 11 cultures. Immunohistology utilizing specific antisera demonstrated the presence of respiratory syncytial virus antigen(s) in 7 or 7 patients. Negative results were obtained with antisera to a variety of paramyxoviruses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Bone and Bones / ultrastructure
  • Capsid / ultrastructure
  • Cells, Cultured
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteitis Deformans / microbiology
  • Osteitis Deformans / pathology*
  • RNA
  • Respiratory Syncytial Viruses

Substances

  • RNA