Abstract
Interferon (IFN) was found to be secreted by cloned lines of murine cytotoxic T lymphocytes in response to mitogenic or antigen specific stimulation. The IFN produced was shown to be of the immune type based on its sensitivity to pH 2.0 and on the ability of an antiserum to immune IFN to neutralize the antiviral activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens
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Clone Cells / immunology
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Concanavalin A / pharmacology
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Cytotoxicity, Immunologic*
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Epitopes
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Interferons / biosynthesis*
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Interferons / immunology
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Mice
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Mice, Inbred BALB C
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
Substances
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Antigens
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Epitopes
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Concanavalin A
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Interferons