Abstract
Twelve patients with recurrent breast cancer were treated with Peplomycin monotherapy. Peplomycin was given intermittently with a dose of 10 mg intramuscularly twice a week. As side effects of Peplomycin, fever elevation in 75% (9/12), malaise in 67%, nausea and vomiting in 42%, anorexia in 42%, pulmonary toxicity in 8%, and loss of hair in 8%, were observed. Out of 8 evaluable cases, CR was obtained in 1, PR in 1, NC in 3, and PD in 3 cases, respectively.
MeSH terms
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Adult
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Aged
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Antibiotics, Antineoplastic / administration & dosage*
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Antibiotics, Antineoplastic / adverse effects
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Bleomycin / administration & dosage
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Bleomycin / adverse effects
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Breast Neoplasms / drug therapy*
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Carcinoma, Intraductal, Noninfiltrating / drug therapy*
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Carcinoma, Papillary / drug therapy*
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Drug Evaluation
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Female
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Humans
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Lung Neoplasms / secondary
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Recurrence, Local
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Peplomycin
Substances
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Antibiotics, Antineoplastic
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Bleomycin
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Peplomycin