Abstract
The in vitro activity of norfloxacin (MK-0366), a new oral antimicrobial agent, was compared to that of ampicillin, tetracycline, cefazolin, nitrofurantoin, nalidixic acid, and trimethoprim against 199 gram-negative urinary isolates. Among these isolates were ampicillin-resistant Escherichia coli and gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens. Norfloxacin was the most active antimicrobial agent tested against all isolates studied; it was the only agent active against P. aeruginosa and S. marcescens.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents, Urinary / pharmacology*
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Drug Resistance, Microbial
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Escherichia coli Infections / drug therapy
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Humans
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In Vitro Techniques
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Klebsiella Infections / drug therapy
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Klebsiella pneumoniae / drug effects
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Nalidixic Acid / analogs & derivatives*
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Nalidixic Acid / pharmacology
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Norfloxacin
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Pseudomonas Infections / drug therapy
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Serratia marcescens / drug effects
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Urinary Tract Infections / drug therapy*
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Urinary Tract Infections / microbiology
Substances
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Anti-Infective Agents, Urinary
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Nalidixic Acid
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Norfloxacin