Abstract
We have administered cefotiam intravenously to 23 pediatric patients. The daily dose was 13-210 mg/kg. The clinical responses were excellent and good in 20 cases. Excluding 1 case with infectious mononucleosis, the efficacy rate of 90.9% (20/22 cases) was achieved As for side effect, diarrhea and eosinophilia were observed one each in 2 cases. In 2 cases, half lives were 24 and 53 minutes, urinary recovery rates were 88.3 and 91% over 6 hours.
MeSH terms
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Age Factors
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Infections / drug therapy*
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Cefotaxime / adverse effects
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Cefotaxime / analogs & derivatives*
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Cefotaxime / metabolism
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Cefotaxime / therapeutic use
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Cefotiam
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Child
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Child, Preschool
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Drug Evaluation
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Female
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Humans
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Infant
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Infant, Newborn
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Injections, Intravenous
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Kinetics
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Male
Substances
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Anti-Bacterial Agents
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Cefotiam
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Cefotaxime