Abstract
The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome.
MeSH terms
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Base Sequence
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Biological Evolution
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Cloning, Molecular
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DNA Restriction Enzymes
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Genes
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Genetic Linkage
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Humans
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Immunoglobulin Constant Regions / genetics*
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Immunoglobulin Light Chains / genetics*
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Immunoglobulin Variable Region / genetics
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Immunoglobulin lambda-Chains / genetics*
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Immunoglobulins / genetics*
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Polymorphism, Genetic
Substances
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Immunoglobulin Constant Regions
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Immunoglobulin Light Chains
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Immunoglobulin Variable Region
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Immunoglobulin lambda-Chains
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Immunoglobulins
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DNA Restriction Enzymes
Associated data
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GENBANK/J00252
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GENBANK/J00253
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GENBANK/J00254