An evaluation of 801 cases of different forms of uterine trophoblastic tumors treated at the Center in 1960-1981 is given. Chorionepithelioma was confirmed histologically in 488 cases. Modern means of diagnosis of uterine trophoblastic tumors are discussed. A retrospective analysis of treatment of patients is presented. The result of up-to-date combination chemotherapy of patients with uterine chorionepithelioma are reported. The role of surgery in the treatment of trophoblastic tumors is discussed.