Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta

Infect Immun. 1983 Apr;40(1):172-6. doi: 10.1128/iai.40.1.172-176.1983.

Abstract

Human interferon-gamma was more effective than interferon-beta or -alpha in stimulating production of immunoassociated antigens; HLA-A, -B, and -C; and beta(2)-microglobulin in human M14 and Namalva cells. The comparison was made on the basis of antiviral units, and the stimulation could be abolished by treatment of the interferon-gamma preparation with pH 2 or anti-interferon-gamma serum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • HLA Antigens / analysis*
  • HLA Antigens / immunology
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class II / analysis
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Interferon Type I / physiology*
  • Rabbits
  • Vesicular stomatitis Indiana virus / growth & development
  • Virus Replication
  • beta 2-Microglobulin / analysis
  • beta 2-Microglobulin / immunology

Substances

  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class II
  • Interferon Type I
  • beta 2-Microglobulin