In vivo regulation of the uvrA gene: role of the "-10" and "-35" promoter regions

Nucleic Acids Res. 1983 Sep 10;11(17):5795-810. doi: 10.1093/nar/11.17.5795.

Abstract

The effect of increasing deletions in the uvrA promoter region on the transcriptional efficiency was quantitatively analysed by fusion to the galK structural gene. A physical analysis of uvrA messenger RNA synthesis from the different deletion plasmids was performed using the S1 mapping technique. Both methods indicate that the uvrA "-10" promoter sequence is sufficient to trigger uvrA transcription. Although not essential, the "-35" region, which is overlapping with the LexA binding site, is shown to have an enhancing function, as the exposure of this region after SOS induction results in a 3- to 4-fold increase in uvrA transcription. A model is presented which accounts both for the observed basal and induced expression of the uvrA gene on a molecular level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / genetics*
  • Base Sequence
  • Cloning, Molecular*
  • Enzyme Induction
  • Escherichia coli / genetics*
  • Galactokinase / genetics
  • Genes*
  • Genes, Bacterial*
  • Kinetics
  • Operon*
  • Plasmids

Substances

  • Bacterial Proteins
  • Galactokinase

Associated data

  • GENBANK/X01621