Abstract
A putative T-cell receptor gene was isolated from the DNA of the helper hybridoma, 2B4 . Analysis of the sequence components of this rearranged gene indicates the presence of separate variable (V), diversity (D) and joining (J) region elements analogous to those of heavy-chain immunoglobulins. These findings further support the belief that the products of this locus are involved in antigen recognition by T cells. There is no evidence of somatic mutation between the putative germ-line and the expressed variable-region gene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular*
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DNA / isolation & purification
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DNA Restriction Enzymes
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Genes*
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Hybridomas / immunology
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Immunoglobulin J-Chains / genetics
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Immunoglobulin Variable Region / genetics
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Mice
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RNA, Messenger / genetics
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Receptors, Antigen, T-Cell / genetics*
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T-Lymphocytes / immunology
Substances
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Immunoglobulin J-Chains
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Immunoglobulin Variable Region
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RNA, Messenger
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Receptors, Antigen, T-Cell
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DNA
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DNA Restriction Enzymes
Associated data
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GENBANK/K02548
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GENBANK/X00619
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GENBANK/X00620
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GENBANK/X00621
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GENBANK/X00622