Presence of human papillomavirus in genital tumors

J Invest Dermatol. 1984 Jul;83(1 Suppl):26s-28s. doi: 10.1111/1523-1747.ep12281143.

Abstract

Human papillomavirus (HPV) types 16 and 18 have been identified in two different human cervical carcinomas. The viral DNAs were molecularly cloned and used as probes to screen a large number of genital tumors by Southern blot analysis. HPV-16 or HPV-18 sequences, respectively, were found in a high percentage of cervical carcinomas, but only in a small number of condylomata acuminata or flat condylomas. The majority of the latter lesions, however, contained HPV-6 or HPV-11 sequences, respectively, which in contrast were detected only rarely in carcinomas in situ or invasively growing carcinomas. A similar distribution of the different papillomaviruses was observed when cell swabs taken from the cervix were tested by in situ hybridization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cloning, Molecular
  • Condylomata Acuminata / microbiology*
  • DNA, Viral / genetics
  • Female
  • Humans
  • Nucleic Acid Hybridization
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Tumor Virus Infections / microbiology*
  • Uterine Cervical Neoplasms / microbiology*
  • Vaginal Smears

Substances

  • DNA, Viral