Abstract
Methyl 4-O-(4-alpha-D-glucopyranosyloxy-4-methoxybutyl)-alpha-D-glu copyranoside (9) was synthesised by transacetalation from methyl 2,3,6-tri-O-acetyl-4-O-(4,4-dimethoxybutyl)-alpha-D-glucopyranosid e and trimethylsilyl 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranoside followed by removal of the blocking groups. Compound 9, which is methyl alpha-maltotrioside modified by replacing the middle D-glucosyl residue with an acyclic spacer, competitively inhibits the hydrolysis of p-nitrophenyl alpha-maltotrioside by porcine alpha-amylase.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, Gas
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Methylglucosides / chemical synthesis*
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Methylglycosides / chemical synthesis*
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Oligosaccharides / chemical synthesis*
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Pancreas / enzymology
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Protein Binding
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Proteins / metabolism*
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Structure-Activity Relationship
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Swine
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alpha-Amylases / metabolism
Substances
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Indicators and Reagents
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Methylglucosides
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Methylglycosides
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Oligosaccharides
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Proteins
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methyl 4-O-(4 alpha-glucopyranosyloxy-4-methoxybutyl)-alpha-glucopyranoside
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alpha-Amylases