Yeast killer dsRNA plasmids are transcribed in vivo to produce full and partial-length plus-stranded RNAs

Nucleic Acids Res. 1983 Feb 25;11(4):1077-97. doi: 10.1093/nar/11.4.1077.

Abstract

In vivo transcripts of the L (4.5 kb) and M (1.9 kb) dsRNA plasmids were examined in type I killers of Saccharomyces cerevisiae. Transcripts for both plasmids include full-length (l,m) and partial-length (la,ma) single-stranded species. Both L-dsRNA transcripts (l,la) have in vitro mRNA activity for L-P1, previously shown to be identical to ScV-P1, the 88,000 dalton major capsid protein of the virus-like particles containing L- and M1-dsRNAs. 1, but not 1a, is bound to poly(U)-sepharose and may be polyadenylated. Other L-dsRNA gene products and their transcripts may exist. For M1-dsRNA, both species (m, ma) have in vitro mRNA activity for M1-P1, the 32,000 dalton pre-protoxin encoded by M1-dsRNA. Both m and ma are bound to poly(U)-Sepharose and ma is probably a 5' terminal fragment of m. A functional model for M1-dsRNA killer plasmid structure is presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Capsid / genetics
  • Molecular Weight
  • Mutation
  • Plants / metabolism
  • Plasmids*
  • Protein Biosynthesis
  • RNA, Double-Stranded / genetics*
  • RNA, Messenger / genetics
  • Reticulocytes / metabolism
  • Saccharomyces cerevisiae / genetics*
  • Transcription, Genetic*
  • Triticum / metabolism

Substances

  • RNA, Double-Stranded
  • RNA, Messenger