Abstract
Two patients with advanced lymphoma involving the lungs that was resistant to chemotherapy had an initial excellent response to interferon therapy. After two months of stable disease, alpha interferon A therapy was discontinued, with relapse of a few months later. Both patients had extensive pulmonary involvement with relapse of the lymphoma, and both showed a dramatic response to retreatment with alpha interferon A. Unusual interferon-related pulmonary complications were observed in one patient, and their management is detailed.
Publication types
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Case Reports
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Clinical Trial
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Clinical Trials as Topic
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DNA, Recombinant
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Humans
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Interferon Type I / adverse effects
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Interferon Type I / genetics
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Interferon Type I / therapeutic use*
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / therapy*
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Lymphatic Metastasis
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Lymphoma / diagnostic imaging
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Lymphoma / therapy*
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Male
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Neoplasm Recurrence, Local / therapy*
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Radiography
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Respiratory Distress Syndrome / etiology
Substances
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Adrenal Cortex Hormones
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DNA, Recombinant
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Interferon Type I