Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci

Infect Immun. 1983 Oct;42(1):122-5. doi: 10.1128/iai.42.1.122-125.1983.

Abstract

Interferon-gamma affected the expression of the products of the immunoassociated antigen complex by a differential modulation of DR- and DC-locus-controlled molecules. In melanoma M14 cells treated with interferon-gamma, levels of DR molecules were increased two- to threefold, whereas levels of DC molecules were increased six- to sevenfold. Similar effects were induced on the two allelic products of each locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Gene Expression Regulation*
  • Genes, MHC Class II*
  • HLA Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • HLA-DR4 Antigen
  • HLA-DR6 Antigen
  • Histocompatibility Antigens Class II*
  • Humans
  • Interferon-gamma / pharmacology*
  • Melanoma

Substances

  • HLA Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • HLA-DR4 Antigen
  • HLA-DR6 Antigen
  • Histocompatibility Antigens Class II
  • Interferon-gamma