Abstract
Some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides (IX-XII) prepared from bicyclo[3.2.1]octan-3-one (I), were assayed in vitro against influenza A viruses. All materials showed activity similar to 1-adamantanamine hydrochloride. A 1H-NMR study revealed only one isomer at the spiro carbon atom.
MeSH terms
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Adamantane / pharmacology
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Antiviral Agents / chemical synthesis*
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Bridged Bicyclo Compounds / chemical synthesis*
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Bridged Bicyclo Compounds / pharmacology
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Bridged-Ring Compounds / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Influenza A virus / drug effects*
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Isomerism
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Magnetic Resonance Spectroscopy
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / pharmacology
Substances
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Antiviral Agents
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Bridged Bicyclo Compounds
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Bridged-Ring Compounds
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Pyrrolidines
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Adamantane