Aim of the present paper is to study the modifications of some laboratory parameters most related to glycaemic metabolism during 24 hours of feed-back glycaemic control by artificial beta-cell. Twelve subjects affected by insulin dependent diabetes mellitus were submitted to GCIIS BIOSTATOR Miles evaluating, before and after 24 hours, blood tryglicerides, cholesterol, uric acid, sodium, potassium. A significant variation was found between the trygliceridemic values before and after automatic control. There was no variation in natriemic values before and after control. Variations, but not significant, were found in cholesterolemic, kaliemic and uricacidaemic values.