A gene controlling teratocarcinoma graft rejection mapped inside the t0 haplotype

Cell Differ. 1984 Dec;15(2-4):235-9. doi: 10.1016/0045-6039(84)90080-0.

Abstract

The embryo-derived teratocarcinoma TC1Ph of the genotype (129 t0/T X C3H)t0/+ and embryonal carcinoma (EC) cell line EC1Ph, established from the TC1Ph, were used as grafts for mice differing only at the T-H-2 interval of chromosome 17. Using exceptional recombinants in this chromosome region a two-gene model of genetic control of EC histocompatibility was proposed. The Cech-1 gene situated at the T end of the T-H-2 interval would control expression of the EC histocompatibility gene located near the H-2 complex.

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Genes*
  • Graft Rejection*
  • Histocompatibility
  • Mice
  • Models, Genetic
  • Neoplasm Transplantation
  • Teratoma / pathology*