Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma

Br J Haematol. 1984 Jul;57(3):393-405. doi: 10.1111/j.1365-2141.1984.tb02913.x.

Abstract

Chromosome abnormality involving band 8q24 is present in the malignant cells in virtually all 'Burkitt's' type malignancies. t(8;14)(q24;q32) translocations have nevertheless been found in certain cases of malignant lymphomas (ML) described as 'small non-cleaved non-Burkitt', 'immunoblastic' or 'histiocytic'. With a view to comparing objectively the histological picture of such lymphomas, we undertook morphometric analysis of seven cases of diffuse ML classed as 'Burkitt's' (three cases), 'immunoblastic' (two cases), 'small non-cleaved non-Burkitt' (one case) and 'large-cell lymphoma' (one case), all exhibiting band 8q24 rearrangement arising from various translocations. Our study substantiates the view that the histologic picture of MLs with 8q24 anomaly fits into a morphological continuum containing 'Burkitt's', 'small non-cleaved non-Burkitt' and 'immunoblastic' lymphomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Burkitt Lymphoma / genetics
  • Child
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosomes, Human, 6-12 and X*
  • Female
  • Humans
  • Karyotyping
  • Lymph Nodes / pathology
  • Lymphoma / genetics*
  • Lymphoma / immunology
  • Lymphoma / pathology
  • Lymphoma, Non-Hodgkin / genetics
  • Male
  • Middle Aged
  • Receptors, Antigen, B-Cell / analysis
  • Translocation, Genetic

Substances

  • Receptors, Antigen, B-Cell