Abstract
2 primary immune responses (anti-SRBC antibody response and allograft rejection) have been tested in mice at various time intervals after single doses of either DTIC or cyclophosphamide. The DTIC-induced immunodepression proved to be extremely long-lasting, being still detectable after 2 months.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibody Formation / drug effects
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Cyclophosphamide / pharmacology
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Dacarbazine / pharmacology*
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Female
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Graft Rejection / drug effects
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Immunosuppressive Agents*
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Male
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Mice
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Neoplasm Transplantation
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Triazenes / pharmacology*
Substances
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Immunosuppressive Agents
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Triazenes
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Dacarbazine
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Cyclophosphamide