Biochemical studies on structural and nonstructural proteins of the African green monkey B-lymphotropic papovavirus (LPV)

Virology. 1983 Jun;127(2):469-74. doi: 10.1016/0042-6822(83)90160-5.

Abstract

African green monkey (AGM) B-lymphotropic papovavirus (LPV) particles were separated from infected B-lymphoma BJA-B cells by neuraminidase and deoxycholate treatment and were further purified twice by CsCl density centrifugation. The SDS-PAGE analysis of virus particles banding at a density of 1.3510 g/ml and radioactively labeled by 125I revealed a major polypeptide of 40,000 and two minor polypeptides of 42,000 and 29,000. In addition, in infected BJA-B cells, all three viral structural polypeptides could be identified by immunoprecipitation. A nonstructural phosphopolypeptide of approximately 90,000 MW could be detected when sera against SDS-denatured SV40 T antigen or an AGM serum pool were used for immunoprecipitation. It is suggested that the 90K polypeptide of LPV represents an equivalent to T antigens of other papovaviruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / analysis
  • Antigens, Viral, Tumor
  • B-Lymphocytes / microbiology
  • Cell Line
  • Chlorocebus aethiops
  • Humans
  • Molecular Weight
  • Papillomaviridae / analysis*
  • Papillomaviridae / immunology
  • Papillomaviridae / isolation & purification
  • Polyomaviridae*
  • Viral Proteins / analysis*
  • Viral Structural Proteins

Substances

  • Antigens, Viral
  • Antigens, Viral, Tumor
  • Viral Proteins
  • Viral Structural Proteins