Abstract
Starting from hellebrigenin, orally cardiotonic active acylcardiosteroid derivatives have been synthesized. D 12316 (acrihellin), the hellebrigenin-3 beta-dimethylacrylate, has been chosen for clinical evaluation.
MeSH terms
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Animals
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Bufanolides / chemical synthesis*
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Bufanolides / metabolism
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Bufanolides / pharmacology
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Cardiac Glycosides / chemical synthesis*
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Cardiac Glycosides / metabolism
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Cardiac Glycosides / pharmacology
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Cats
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Chemical Phenomena
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Chemistry
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Digoxin / pharmacology
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Electrocardiography
Substances
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Bufanolides
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Cardiac Glycosides
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hellebrigenin
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Digoxin