[Complex therapy of melanoma metastases in the lung]

Med Radiol (Mosk). 1984 Feb;29(2):7-10.
[Article in Russian]

Abstract

The authors present the therapeutic results of 25 patients with melanoma metastases of the lungs: 9 of them received radiotherapy only, 16 radiotherapy combined with i.v. injection of the antitumor antibiotic dactinomycin. The technique of large field irradiation of the lungs was employed as a single exposure (depending on tumor spread) of the entire volume of one or both lungs. The treatment resulted in a decrease of metastases by more than 50% of the initial value in 2 out of 6 patients in the 1st group; in the 2nd group in 16 patients metastases disappeared, in 2 patients they decreased by 50%. Pulmonites prevailed in the group of multiple modality treatment. The authors conclude that dactinomycin raises to a higher power the degree of radiation exposure of melanoma metastases as well as the normal lung tissue.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Dactinomycin / therapeutic use
  • Female
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / radiotherapy
  • Lung Neoplasms / secondary*
  • Male
  • Melanoma / drug therapy
  • Melanoma / radiotherapy
  • Melanoma / secondary*
  • Middle Aged

Substances

  • Dactinomycin