Abstract
We compared auranofin (AF) in a single blind multi-centre study with gold sodium thiomalate and D-penicillamine in the treatment of rheumatoid arthritis. Adult patients with disease duration 6-60 months without previous treatment with gold salts with persistent active disease, were included. Thirty-nine patients, 13 in each treatment group, have so far been entered. Cumulative toxicity data and some results of efficacy assessments in those completing 9 months of treatment are presented. AF is very well tolerated, judgment concerning efficacy must await the end of the trial.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Arthritis, Rheumatoid / drug therapy*
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Auranofin
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Aurothioglucose / adverse effects
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Aurothioglucose / analogs & derivatives*
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Aurothioglucose / therapeutic use
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Female
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Gold / analogs & derivatives*
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Gold Sodium Thiomalate / adverse effects
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Gold Sodium Thiomalate / therapeutic use*
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Humans
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Male
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Middle Aged
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Outcome and Process Assessment, Health Care
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Penicillamine / adverse effects
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Penicillamine / therapeutic use*
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Time Factors
Substances
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Gold Sodium Thiomalate
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Aurothioglucose
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Auranofin
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Gold
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Penicillamine