Abstract
3 patients with multiple myeloma developed hyperkalemic hypoaldosteronism and renal insufficiency while receiving indomethacin for bone pain. Claims are made that indomethacin has been responsible for these complications, possibly by inhibiting prostaglandin biosynthesis. Careful observation of myeloma patients during administration of this agent and perhaps other prostaglandin inhibitors appears warranted.
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / complications
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Aged
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Female
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Humans
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Hyperkalemia / chemically induced*
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Hyperkalemia / complications
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Indomethacin / adverse effects*
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Indomethacin / therapeutic use
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Kidney Function Tests
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Male
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Middle Aged
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Multiple Myeloma / complications*
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Multiple Myeloma / drug therapy
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Prostaglandin Antagonists / adverse effects
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Prostaglandin Antagonists / therapeutic use
Substances
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Prostaglandin Antagonists
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Indomethacin