In 62 sexually mature women in the out-patient department the intra-vaginal contraceptive ovule was inserted by the physician into the posterior vaginal vault and removed 15 minutes later and then weighed. The mean loss of weight was about 24%. Except in one case the ovule remained intact in all other cases the foam development was confined to the upper third of the vagina. With a probability of error of P = 0.12 it can be assumed that the dispersed amount from the ovule is less in older patients than in younger patients. There was no difference in the dispersed amount during in the first and the second half of the menstrual cycle. Further in-vivo investigations on intra-vaginal contraceptive ovules appear to be required.
PIP: In 62 sexually mature women in the outpatient department, an intravaginal contraceptive ovule was inserted by the physician into the posterior vaginal vault and removed 15 minutes later and then weighed. The mean loss of weight was about 24%. Except in 1 case, the ovule remained intact; in all other cases the foam development was confined to the upper 1/3 of the vagina. With a probability of error of P=0.12, it can be assumed that the dispersed amount from the ovule is less in older patients than in younger patients. There was no difference in the dispersed amount between the first and second 1/2 of the menstrual cycle. Further in vivo investigations on intravaginal contraceptive ovules is necessary. (author's)