Abstract
Zymosan, a polysaccharide composed primarily of glucan and mannan residues, activates the complement system through the alternative complement pathway. We showed that zymosan-induced complement activation is inhibited by zymosan-bound lectins with carbohydrate specificities for mannosyl and glycosyl residues. Lectins unable to bind mannosyl or glucosyl residues did not inhibit zymosan-induced complement activation.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Complement Activation*
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Complement C1 / metabolism
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Complement C3 / metabolism
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Complement Factor B / metabolism
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Complement Pathway, Alternative*
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Concanavalin A / metabolism
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Concanavalin A / pharmacology*
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Humans
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Lectins / pharmacology
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Zymosan / metabolism
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Zymosan / pharmacology*
Substances
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Complement C1
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Complement C3
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Lectins
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Concanavalin A
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Zymosan
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Complement Factor B