Abstract
The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation sites.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Binding Sites
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Blood Coagulation Disorders / metabolism
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Blood Coagulation* / drug effects
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Calcium / pharmacology
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Fibrin / metabolism*
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Fibrinogen / metabolism*
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Fibrinopeptide A / metabolism
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Fibrinopeptide B / metabolism
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Humans
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Kinetics
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Macromolecular Substances
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Protein Binding
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Thrombin / metabolism
Substances
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Macromolecular Substances
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Fibrinopeptide A
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Fibrinopeptide B
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Fibrin
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Fibrinogen
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Thrombin
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Calcium