The HLA antigens are currently investigated in many diseases and are very useful in medico-legal tests for exclusion of paternity. However, because of the high polymorphism of the HLA system, for a correct interpretation of the results, it is essential to know the HLA antigens distribution in normal populations used as control. Up to now there are few studies about the HLA system in different regions of Italy and for this reason the Authors have studied the phenotypic, genic frequency and the gametic association of HLA A and B antigens in a population living in the province of Parma. The results confirm an HLA homogeneity of populations living it the western territories of the Emilia Region.