Synthesis of C-11 iodoantipyrine for positron emission tomography

J Nucl Med. 1981 Jun;22(6):538-41.

Abstract

We have developed a method for the synthesis of C-11 iodoantipyrine. Carbon-11-labeled methyl iodide, prepared from 11CO2, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Following silica-gel column chromatography and iodination, radiochemical purity of the C-11 iodoantipyrine was more than 99.5%, with a 10% yield and a specific activity of 30 mCi/mumol. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antipyrine / analogs & derivatives*
  • Antipyrine / chemical synthesis
  • Brain / blood supply
  • Brain / diagnostic imaging
  • Carbon Radioisotopes*
  • Cerebrovascular Circulation
  • Isotope Labeling / methods*
  • Rats
  • Tomography, Emission-Computed* / methods

Substances

  • Carbon Radioisotopes
  • Antipyrine
  • iodoantipyrine