Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin

J Pharmacol Exp Ther. 1982 Apr;221(1):215-21.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biotransformation
  • Cytochrome P-450 Enzyme System / metabolism*
  • Dealkylation
  • Enzyme Induction / drug effects
  • In Vitro Techniques
  • Liver / enzymology
  • Male
  • Microsomes, Liver / metabolism
  • Mixed Function Oxygenases / metabolism
  • Oleandomycin / metabolism
  • Oleandomycin / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Troleandomycin / metabolism
  • Troleandomycin / pharmacology*

Substances

  • Cytochrome P-450 Enzyme System
  • Troleandomycin
  • Mixed Function Oxygenases
  • Oleandomycin