Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity

Biochem Pharmacol. 1978;27(8):1203-9. doi: 10.1016/0006-2952(78)90453-7.
No abstract available

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors*
  • Benzopyrene Hydroxylase / antagonists & inhibitors*
  • Benzopyrenes / antagonists & inhibitors*
  • Cytochrome P-450 Enzyme System / metabolism*
  • DNA / metabolism
  • Ellipticines / metabolism
  • Ellipticines / pharmacology*
  • In Vitro Techniques
  • Male
  • Microsomes, Liver / enzymology
  • Mutagens / antagonists & inhibitors*
  • Rats
  • Salmonella / drug effects
  • Salmonella / genetics

Substances

  • Alkaloids
  • Benzopyrenes
  • Ellipticines
  • Mutagens
  • DNA
  • Cytochrome P-450 Enzyme System
  • Benzopyrene Hydroxylase
  • Aryl Hydrocarbon Hydroxylases