Abstract
This multicenter double-blind clinical trial compared the efficacy and safety of benoxaprofen and naproxen in the treatment of rheumatoid arthritis. The studies followed a crossover design which provided 6 wk therapy with each of the 2 study drugs. Benoxaprofen at a single daily dose of 600 mg compared favorably to naproxen, 750 mg, administered in 2 equally divided doses. All efficacy results indicated slightly more improvement with benoxaprofen although the difference between the 2 drugs was not significant. Side effects were generally mild and only 1 patient discontinued benoxaprofen therapy because of a reactivation of a duodenal ulcer.
Publication types
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Clinical Trial
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Comparative Study
MeSH terms
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Adult
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Aged
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Analysis of Variance
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / blood
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Anti-Inflammatory Agents / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Benzoxazoles / adverse effects
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Benzoxazoles / blood
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Benzoxazoles / therapeutic use*
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Blood Sedimentation
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Clinical Trials as Topic
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Double-Blind Method
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Female
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Humans
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Male
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Middle Aged
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Naproxen / therapeutic use*
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Patient Compliance
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Propionates / adverse effects
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Propionates / blood
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Propionates / therapeutic use*
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Time Factors
Substances
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Anti-Inflammatory Agents
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Benzoxazoles
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Propionates
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benoxaprofen
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Naproxen