Abstract
Renin-free nerve growth factor causes the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia from neonatal rats but not in the brain of mature rats. Less pure preparations of nerve growth factor induce the enzyme in both brain and ganglia. The induction of ornithine decarboxylase in the central nervous system appears to be due to renin, not to nerve growth factor itself.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Angiotensin II / pharmacology
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Animals
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Brain / enzymology*
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Carboxy-Lyases / biosynthesis*
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Drinking Behavior / drug effects
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Enzyme Induction / drug effects
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Ganglia / enzymology*
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Liver / enzymology
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Male
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Nerve Growth Factors / pharmacology*
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Ornithine Decarboxylase / biosynthesis*
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Rats
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Renin / pharmacology*
Substances
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Nerve Growth Factors
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Angiotensin II
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Renin
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Carboxy-Lyases
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Ornithine Decarboxylase