Abstract
The combination of mitomycin C, methyl-CCNU and 5-fluorouracil produced no objective tumor regressions in 25 evaluable patients with metastatic colorectal carcinoma. Patients who achieved stable disease survived significantly longer than patients who had progressive disease. This difference appeared to be more probably related to pre-treatment characteristics of the patients than caused by treatment. Serial CEA determinations revealed a parallel relationship with tumor behavior in 17 of 19 patients.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Clinical Trials as Topic
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / mortality
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Drug Therapy, Combination
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Fluorouracil / administration & dosage*
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Fluorouracil / toxicity
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Follow-Up Studies
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Humans
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Liver Neoplasms / secondary
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Lomustine / administration & dosage*
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Lomustine / analogs & derivatives
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Lomustine / toxicity
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Middle Aged
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Mitomycins / administration & dosage*
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Mitomycins / toxicity
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Nitrosourea Compounds / administration & dosage*
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / mortality
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Remission, Spontaneous
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Time Factors
Substances
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Mitomycins
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Nitrosourea Compounds
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Lomustine
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Fluorouracil