Abstract
The Cancer and Leukemia Group B (CALB) has conducted a randomized study of adjuvant chemotherapy in patients with breast cancer who have involved axillary nodes at the time of mastectomy. Five-drug treatment (CMFVP) was compared with three-drug treatment (CMF). For patients with more than three involved nodes, the CMFVP regimen produced a significantly prolonged disease-free survival in comparison to the CMF regimen.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Breast Neoplasms / drug therapy*
-
Breast Neoplasms / surgery
-
Clinical Trials as Topic
-
Cyclophosphamide / therapeutic use*
-
Drug Administration Schedule
-
Drug Therapy, Combination
-
Female
-
Fluorouracil / therapeutic use*
-
Follow-Up Studies
-
Humans
-
Immunotherapy
-
Mastectomy
-
Methotrexate / therapeutic use*
-
Mycobacterium bovis / immunology
-
Prednisone / therapeutic use*
-
Vincristine / therapeutic use*
Substances
-
Vincristine
-
Cyclophosphamide
-
Fluorouracil
-
Prednisone
-
Methotrexate