[Identification of the reactive sites of kidney bean proteinase inhibitor]

V V Mosolov; T A Valueva; E L Malova; G V Kolosova; A N Cheban

[Identification of the reactive sites of kidney bean proteinase inhibitor]

Biokhimiia. 1982 Apr;47(4):561-8.

[Article in Russian]

Authors

V V Mosolov, T A Valueva, E L Malova, G V Kolosova, A N Cheban

PMID: 7082689

Abstract

The protein proteinase inhibitor from kidney bean (isoinhibitor, pI 4.3) is a double-headed inhibitor with independent reactive sites for trypsin and chymotrypsin. The reactive site of the inhibitor for trypsin is Lys (22)- Ser (23) in the sequense ...-Lys-Ser-Ile-Pro-Ala-Glx-Cys-Arg-..., the reactive site for chymotrypsin is Leu (64)-Ser (65) in the sequence ...-Thr-Leu-Ser-Ile-Pro-Ala-Glx-Cys-Arg-... .

Publication types

English Abstract

MeSH terms

Amino Acid Sequence
Binding Sites
Chymotrypsin / antagonists & inhibitors*
Kinetics
Trypsin Inhibitors / pharmacology*

Substances

Trypsin Inhibitors
Chymotrypsin