Aggregation of cell surface receptors by multivalent ligands

J Math Biol. 1982;14(3):365-70. doi: 10.1007/BF00275399.

Abstract

Using a combination of branching processes and kinetic equations a solution is provided to the problem of describing the size of aggregates formed on cell surfaces when multivalent ligands bind and cross-link multivalent receptors. A criterion is given for the onset of gelation in infinite 2-dimensional systems, which may be relevant to the phenomenon of ligand-induced receptor patching.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Membrane / physiology
  • Kinetics
  • Ligands
  • Macromolecular Substances
  • Mathematics
  • Models, Biological
  • Receptors, Drug / physiology*

Substances

  • Ligands
  • Macromolecular Substances
  • Receptors, Drug