Effects of 15-hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system

Eur J Immunol. 1982 Sep;12(9):773-7. doi: 10.1002/eji.1830120913.

Abstract

The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15-HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A-induced blast transformation of human lymphocytes. This inhibition was HLA-linked. HLA-B12 subjects were less sensitive than non-B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Arachidonic Acids / pharmacology*
  • Concanavalin A / pharmacology
  • Erythrocytes / immunology
  • HLA Antigens
  • Humans
  • Immunosuppressive Agents*
  • In Vitro Techniques
  • Leukotrienes*
  • Lipid Peroxides*
  • Lymphocyte Activation / drug effects
  • Lymphocytes / drug effects*
  • Lymphocytes / immunology
  • Rosette Formation
  • Sheep

Substances

  • Arachidonic Acids
  • HLA Antigens
  • Immunosuppressive Agents
  • Leukotrienes
  • Lipid Peroxides
  • Concanavalin A
  • 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid