Abstract
Wilson's disease in a young woman presenting with an acute course is described. The clinical manifestations were fulminant hepatic failure associated with marked intravascular hemolysis. Immediate D-penicillamine and high-dose steroid therapy did not influence the course of the disease. Necropsy revealed an increased hepatic copper content and cirrhosis with extensive necrosis of the liver.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adolescent
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Ceruloplasmin / blood
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Copper / analysis
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Copper / urine
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Female
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Glucocorticoids / therapeutic use
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Hemolysis*
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Hepatolenticular Degeneration / complications
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Hepatolenticular Degeneration / diagnosis
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Hepatolenticular Degeneration / drug therapy*
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Humans
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Liver Diseases / diagnosis*
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Liver Diseases / etiology
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Middle Aged
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Penicillamine / therapeutic use*
Substances
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Glucocorticoids
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Copper
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Ceruloplasmin
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Penicillamine