Abstract
A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.
MeSH terms
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Anesthesia
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Animals
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Antihypertensive Agents / chemical synthesis*
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Benzoxepins / chemical synthesis*
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Benzoxepins / pharmacology
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Blood Pressure / drug effects
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Cats
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Chemical Phenomena
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Chemistry
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Denervation
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Dogs
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Female
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Male
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Pressoreceptors / physiology
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Rats
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Time Factors
Substances
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Antihypertensive Agents
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Benzoxepins