Abstract
In a prospective, randomized, cooperative group trial, the value of iv vincristine and intrathecal methotrexate and hydrocortisone as adjuvant therapy to radiotherapy in children with medulloblastoma and ependymoma was evaluated. The data showed no improvement in the survival of such children when adjuvant therapy was given.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Brain Neoplasms / drug therapy
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Brain Neoplasms / radiotherapy
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Brain Neoplasms / surgery
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Child, Preschool
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Drug Therapy, Combination
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Ependymoma / drug therapy*
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Ependymoma / radiotherapy
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Ependymoma / surgery
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Humans
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Hydrocortisone / administration & dosage*
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Medulloblastoma / drug therapy*
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Medulloblastoma / radiotherapy
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Medulloblastoma / surgery
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Methotrexate / administration & dosage*
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Probability
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Prognosis
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Radiotherapy Dosage
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Random Allocation
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Time Factors
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Vincristine / administration & dosage*
Substances
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Vincristine
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Hydrocortisone
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Methotrexate