Abstract
The effect of xanthine derivatives on platelet aggregation, blood coagulation and the rate of thrombus formation has been studied. Some of the compounds have proved to be effective antiaggregative agents both when added to the platelet enriched plasma and administered to the body.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Female
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Hemostasis / drug effects*
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In Vitro Techniques
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Male
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Platelet Adhesiveness / drug effects
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Platelet Aggregation / drug effects*
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Rabbits
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Rats
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Thrombosis / drug therapy
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Xanthines / pharmacology*