FR-900137, a new antibiotic. I. Taxonomy and fermentation of the organism, and isolation and characterization of the antibiotic

Y Kuroda; T Goto; M Okamoto; M Yamashita; E Iguchi; M Kohsaka; H Aoki; H Imanaka

doi:10.7164/antibiotics.33.272

FR-900137, a new antibiotic. I. Taxonomy and fermentation of the organism, and isolation and characterization of the antibiotic

J Antibiot (Tokyo). 1980 Mar;33(3):272-9. doi: 10.7164/antibiotics.33.272.

Authors

Y Kuroda, T Goto, M Okamoto, M Yamashita, E Iguchi, M Kohsaka, H Aoki, H Imanaka

PMID: 7380739
DOI: 10.7164/antibiotics.33.272

Abstract

A strain of Streptomyces, isolated from a soild sample and identified as Streptomyces unzenensis sp. nov. has been found to produce FR-900137, an interesting new antibiotic, containing phosphorus in its molecule. The antibiotic, obtained as white powder, was shown to inhibit a wide variety of Gram-positive and Gram-negative bacteria except Pseudomonas aeruginosa.

MeSH terms

Animals
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Chemical Phenomena
Chemistry, Physical
Culture Media
Drug Resistance, Microbial
Fermentation
Leucine / analogs & derivatives*
Leucine / biosynthesis
Leucine / isolation & purification
Leucine / pharmacology
Mice
Streptomyces / classification*
Streptomyces / metabolism

Substances

Anti-Bacterial Agents
Culture Media
FR 900137
Leucine