Preparation and purification of estriol, estradiol, and progesterone labeled with radioactive iodine

Eur J Nucl Med. 1978 Jul 1;3(3):191-5. doi: 10.1007/BF00256643.

Abstract

Steroids labeled with radioactive isotopes are useful tracers for radio-immunoassay and for in vivo nuclear medecine purposes. We here report and discuss methods for direct labeling of the steroids estriol, estradiol, and progesterone with radioiodine-125 or -131. The purification procedure and some chemical and physical properties of the purified labeled materials are referred to and discussed.

MeSH terms

  • Chloramines
  • Chromatography, Thin Layer
  • Drug Stability
  • Electrophoresis
  • Estradiol / isolation & purification*
  • Estriol / isolation & purification*
  • Iodine / analogs & derivatives
  • Iodine Radioisotopes*
  • Isotope Labeling / methods*
  • Lactoperoxidase
  • Progesterone / isolation & purification*

Substances

  • Chloramines
  • Iodine Radioisotopes
  • Progesterone
  • Estradiol
  • Iodine
  • Lactoperoxidase
  • Estriol